Multiple Choice
Which of the following is the major product when an acid chloride reacts with in a nucleophilic acyl substitution reaction?
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- 1. A Review of General Chemistry5h 5m
- Summary23m
- Intro to Organic Chemistry5m
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- Enolate4m
- Acid-Catalyzed Alpha-Halogentation4m
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- Haloform Reaction8m
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- Overview of Alpha-Alkylations and Acylations5m
- Enolate Alkylation and Acylation12m
- Enamine Alkylation and Acylation16m
- Beta-Dicarbonyl Synthesis Pathway7m
- Acetoacetic Ester Synthesis13m
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- 25. Condensation Chemistry2h 9m
- 26. Amines1h 43m
- 27. Heterocycles2h 0m
- Nomenclature of Heterocycles15m
- Acid-Base Properties of Nitrogen Heterocycles10m
- Reactions of Pyrrole, Furan, and Thiophene13m
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- 28. Carbohydrates5h 53m
- Monosaccharide20m
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- Disaccharide30m
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- 29. Amino Acids4h 20m
- Proteins and Amino Acids19m
- L and D Amino Acids14m
- Polar Amino Acids14m
- Amino Acid Chart1h 18m
- Acid-Base Properties of Amino Acids33m
- Isoelectric Point14m
- Amino Acid Synthesis: HVZ Method12m
- Synthesis of Amino Acids: Acetamidomalonic Ester Synthesis16m
- Synthesis of Amino Acids: N-Phthalimidomalonic Ester Synthesis13m
- Synthesis of Amino Acids: Strecker Synthesis13m
- Reactions of Amino Acids: Esterification7m
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- 30. Peptides and Proteins2h 42m
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- Intro to Citric Acid Cycle7m
- Structures of the Citric Acid Cycle19m
- The Citric Acid Cycle35m
- 34. Nucleic Acids1h 32m
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- Electron Configuration of Elements45m
- Coordination Complexes20m
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- Electron Counting10m
- The 18 and 16 Electron Rule13m
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- Negishi Coupling Reaction16m
- Buchwald-Hartwig Amination Reaction19m
- Eglinton Reaction17m
- Catalytic Allylic Alkylation18m
- Alkene Metathesis23m
- 36. Synthetic Polymers1h 49m
- Introduction to Polymers6m
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- Radical Polymerization15m
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- Polymers Structure and Properties8m
22. Carboxylic Acid Derivatives: NAS
Nucleophilic Acyl Substitution
Struggling with Organic Chemistry?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Determine the major product for the following reaction.
A
B
C
D
Verified step by step guidance1
Identify the reaction type: The reaction involves an ester and an alcohol in the presence of an acid catalyst, which suggests a transesterification reaction.
Understand the mechanism: In transesterification, the alcohol attacks the carbonyl carbon of the ester, leading to the formation of a tetrahedral intermediate.
Protonation step: The acid catalyst protonates the carbonyl oxygen, increasing the electrophilicity of the carbonyl carbon, making it more susceptible to nucleophilic attack by the alcohol.
Nucleophilic attack: The alcohol (isopropanol) acts as a nucleophile and attacks the carbonyl carbon of the ester, forming a tetrahedral intermediate.
Formation of the major product: The intermediate collapses, expelling the original alcohol group (methanol) and forming a new ester with the isopropyl group, resulting in the major product.
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