In the context of molecular interactions, what type of bond is typically broken when $mRNA$ separates from the $DNA$ template during transcription?

• A. $\sigma$ bond
• B. Ionic bond
• C. Hydrogen bond
• D. $\pi$ bond

Answer: (C)

Verified step by step guidance

1. Understand the process of transcription: Transcription is the process by which the information in a strand of DNA is copied into a new molecule of messenger RNA (mRNA).
2. Identify the interaction between DNA and mRNA: During transcription, mRNA is synthesized based on the DNA template strand. The mRNA temporarily pairs with the DNA template through complementary base pairing.
3. Recognize the type of bond involved: The base pairing between DNA and mRNA involves hydrogen bonds. These are weak interactions that occur between the nitrogenous bases of the nucleotides.
4. Determine what happens during separation: When mRNA separates from the DNA template, the hydrogen bonds between the complementary bases are broken. This allows the mRNA to detach and the DNA to re-anneal or remain single-stranded.
5. Conclude the type of bond broken: Since the interaction between mRNA and DNA involves hydrogen bonds, these are the bonds that are typically broken when mRNA separates from the DNA template during transcription.