Prioritize the substituents at each chiral center and then, by each of the two methods discussed in Section 6.3.2.4, determine the absolute configuration. [Do not use your models, except to check your answers.]
(h)

Verified step by step guidance

1. Step 1: Identify the chiral center in the molecule. A chiral center is a carbon atom bonded to four different substituents. In the given structure, the carbon atom attached to CH3, H, O, and the cyclobutane ring is the chiral center.
2. Step 2: Assign priorities to the substituents based on the Cahn-Ingold-Prelog (CIP) rules. The substituent with the highest atomic number gets the highest priority (1). Here, oxygen (O) has the highest atomic number, so it is priority 1. The cyclobutane ring is next, as the carbon directly attached to the chiral center has a higher atomic number than the hydrogen and methyl group. The methyl group (CH3) is priority 3, and hydrogen (H) is priority 4.
3. Step 3: Orient the molecule so that the lowest priority group (H) is pointing away from you. This is typically represented by the dashed wedge in the diagram.
4. Step 4: Determine the order of the remaining substituents (1 → 2 → 3) in a clockwise or counterclockwise direction. If the sequence is clockwise, the configuration is R. If the sequence is counterclockwise, the configuration is S.
5. Step 5: Verify the configuration using the second method discussed in Section 6.3.2.4, which involves visualizing the molecule in 3D or using a systematic approach to confirm the absolute configuration. Ensure that the priorities and orientation are consistent with the rules.

Key Concepts

Chirality and Chiral Centers

Chirality refers to the geometric property of a molecule having non-superimposable mirror images, known as enantiomers. A chiral center, typically a carbon atom, is bonded to four different substituents, leading to two distinct configurations. Understanding chirality is essential for determining the absolute configuration of molecules, which is crucial in organic chemistry, especially in the context of stereochemistry.

Cahn-Ingold-Prelog Priority Rules

The Cahn-Ingold-Prelog (CIP) priority rules are a set of guidelines used to assign priorities to substituents attached to a chiral center. According to these rules, substituents are ranked based on the atomic number of the atoms directly attached to the chiral center, with higher atomic numbers receiving higher priority. This ranking is fundamental for determining the absolute configuration (R or S) of chiral centers in organic molecules.

Absolute Configuration

Absolute configuration refers to the specific three-dimensional arrangement of atoms around a chiral center, designated as either R (rectus) or S (sinister) based on the CIP priority rules. To determine the absolute configuration, one must visualize the molecule in three dimensions and apply the priority rankings to ascertain the orientation of the substituents. This concept is vital for understanding the behavior and reactivity of chiral compounds in chemical reactions.