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Multiple Choice
Provide the major product for the following reaction
A
B
C
D
Verified step by step guidance
1
Identify the starting material as an ester with a beta-keto group, which is a common substrate for Claisen condensation reactions.
The first step involves the use of sodium ethoxide (NaOEt), a strong base, which will deprotonate the alpha hydrogen between the two carbonyl groups, forming an enolate ion.
In the second step, the enolate ion acts as a nucleophile and attacks the benzyl bromide (PhCH2Br) in an SN2 reaction, resulting in the alkylation of the enolate.
The third step involves acidification with H3O+, which will protonate the alkoxide ion formed during the reaction, leading to the formation of a beta-keto ester.
Finally, heating (Δ) will induce decarboxylation, removing the ester group and forming the final ketone product with a phenyl group attached to the alpha position.